In addition to our screen in isogenic KBM7 cells, genome-wide essentialome screens in hundreds of cancer cell lines and several non-transformed cell types suggest that STAG1, in contrast to many other targets of established cancer therapeutics, is not required for proliferation and survival of the vast majority (∼95%) of analyzed cell lines (Meyers et al, 2017; Dempster et al, 2019). The gene discussed is STAG1; the disease is cancer.