IL6 and osteoporosis: Finally, 9 studies met inclusion and exclusion criteria (involving 1891 osteoporosis patients and 2027 healthy controls) [8, 17, 18, 30–35], of which 8 studies explored the relationship between IL-6 174G/C (rs1800795) and osteoporosis, 3 studies reported IL-6 572C/G (rs1800796) and osteoporosis predisposition.