The advantages of current meta-analysis as follows: (1) this is the first meta-analysis to investigate the association between IL-6 572C/G polymorphisms and osteoporosis predisposition; (2) we performed a quality assessment of the literature to ensure the credibility of the pool results; (3) p-value was adjusted after multiple comparisons; (4) we conducted sensitivity analysis to test the stability of the current meta-analysis; (5) compared with previous meta-analysis, the current meta-analysis has a larger sample size. Here, IL6 is linked to osteoporosis.