A combination of magnesium-zinc-calcium-vitamin D during a 12 week period has been associated with a significant decrease of HOMA-IR, insulin, triglycerides, total cholesterol, and VLDL-cholesterol and a significant increase in the QUICKI scores, but it has not been accompanied by changes in LDL-cholesterol, FPG, and HDL-cholesterol in the PCOS patients [14]. The gene discussed is INS; the disease is polycystic ovary syndrome.