Notable findings to date include C11orf95-RELA fusions that define supratentorial ependymoma [20], targetable kinase fusions in pediatric acute lymphoblastic leukemia (ALL) associated with poor outcome [21], NTRK fusions in pediatric high-grade glioma leading to new therapeutic options [39], and targetable MAP3K8 fusion in pediatric melanoma [5]. The gene discussed is MAP3K8; the disease is central nervous system cancer.