NPPB and hydrops fetalis: Among the HF patients with both baseline and follow-up NT-proBNP measurements (n = 69), the reduction in NT-proBNP was observed only in HFrEF patients treated with SGLT2i (from 2202.5 [572.4–6131.4] to 767.5 pg/mL [183.1–1688.7]; p = 0.001), but not in the HFrEF patients without SGLT2i (p for interaction = 0.035 between HFrEF with SGLT2i vs. HFrEF without SGLT2i) (Fig. 4b).