PTGS2 and neoplasm: These genes are encoding: (I) cellular adhesion factors, signaling molecules, and extracellular matrix components (including BMP1, CTNNB1, CDH1, FN1, FZD7, IL1RN, CDH2, VIM, WNT5A); (II) enzymes involved in extracellular matrix remodeling (including MMP2, MMP9) and inflammation (PTGS2); (III) transcription factors (including MYC, SNAI2, SNAI3, TWIST1, ZEB1, ZEB2); (IV) iron-regulatory factors (including FTH1, MELTF, TFRC)—all of which have been shown earlier to control cellular EMT and invasiveness in various tumor types [13,25,26,27,28,29,30,31,32,33,34,35,36,37].