Inflammasomes, such as NLRP3, NLRP1b, and the NLR family CARD domain-containing protein 4 (NLRC4), appear to be mainly expressed in the brain under various pathological conditions, ranging from acute trauma, such as stroke and spinal cord injury, to chronic neurodegeneration, including amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Alzheimer’s disease (AD), psychiatric disorders, including depression and others [23,24,25,33,34,35]. The gene discussed is NLRP3; the disease is major depressive disorder.