NLRP3 and stroke disorder: In general, NLRP3 seems to be mainly responsible for the manifestation of central pain irrespective of the cause and is seen, for instance, in different rodent models, mimicking central post-stroke pain [69], peripherally-induced neuropathic pain [80], migraine [81], hydrogen-rich saline-induced hyperpathia [60], the genesis of trigeminal-induced headache [82], and cingulate cortex allodynia [83].