A very recent study proving as well that CAF-derived exosomes can transfer miRs in BC was conducted by Wang et al. They demonstrated the ability of miR-181d-5p to enhance the aggressiveness of BC through targeting caudal-related homeobox 2 (CDX2), a transcription factor binding to the promoter of homeobox A5 (HOXA5), whose overexpression is known to retard BC cell proliferation, invasion, migration, EMT and apoptosis. This evidence concerns the gene CDX2 and breast cancer.