A very recent study proving as well that CAF-derived exosomes can transfer miRs in BC was conducted by Wang et al. They demonstrated the ability of miR-181d-5p to enhance the aggressiveness of BC through targeting caudal-related homeobox 2 (CDX2), a transcription factor binding to the promoter of homeobox A5 (HOXA5), whose overexpression is known to retard BC cell proliferation, invasion, migration, EMT and apoptosis. The gene discussed is HOXA5; the disease is breast cancer.