MFAP5 and ovarian cancer: In a study conducted in 2014, Leung and colleagues observed that the CAF-derived microfibrillar-associated protein 5 (MFAP5) is a negative prognostic marker in ovarian cancer and that its silencing inhibits the FAK/CREB/TNNC1 signaling pathway and significantly decreases ovarian tumor growth and metastasis in vivo [94].