In initial protein expression and localization analyses, significant amounts of MYSM1 were detectable in a variety of human cell types, including PBMC, KG-1a myeloid leukemia cells, A375 and SK-MEL-28 melanoma cells, HepG2 liver cancer cells, and A172 glioblastoma cells, mainly in the nuclei (Figure S1A–F). Here, MYSM1 is linked to myeloid leukemia.