Another important soluble factor released by stromal cells that participates in melanoma sensitivity to targeted therapies is the Wnt-antagonist, secreted frizzled related protein 2 (sFRP2), the secretion of which by aged fibroblasts from the melanoma microenvironment attenuates the melanoma response to reactive oxygen species (ROS)-induced DNA damage and targeted therapies [87]. The gene discussed is SFRP2; the disease is melanoma.