Immunohistochemical evaluation of tumor tissue has revealed the benefit of the BCG-curcumin combination on a molecular basis, with a maximum decrease of the proliferation markers Ki-67 and cyclin D1, suppression of the angiogenesis relevant molecules CD31 and VEGF, and reduction of the anti-apoptosis biomarkers Bcl-2, Bcl-xL, and survivin. This evidence concerns the gene CCND1 and neoplasm.