CCNA2 and urinary bladder carcinoma: Cell cycle arrest in the T24 bladder cancer cell line exposed to 5–12.5 μM curcumin has been shown to be accompanied by a decrease in the cell cycle regulating protein Cyclin A but not of Cyclin B. Although the Cyclin-dependent kinase (Cdk) inhibitor p21 increases in a dose-dependent manner, both cdk1 and cdk2 remain unchanged, pointing to a particular influence of curcumin on Cyclin A-driven processes [33].