Dubois et al. found that the tumor suppressor gene RASSF1A inhibits YAP through the GEF-H1/RhoB pathway, and they showed that RASSF1A depletion in a mouse model enhances the metastatic potential of the NSCLC cell line H1975 [74]. The gene discussed is RASSF1; the disease is non-small cell lung carcinoma.