INS and Schnyder corneal dystrophy: These metabolic alterations associated with SCD point towards a glycolytic shift and increased insulin sensitivity in this model and to a complex set of metabolites contributing to nociception (NO, arginine, ornithine, ADMA, polyamines, glutamate, aspartate, glycine, taurine, alpha-aminoadipate, kynurenine and serotonin), while the lysophosphatidylcholines, phosphatidylcholines, and sphingomyelins are potentially involved in both pain pathophysiology and RBC remodeling.