The presence of a moderate or strong p16 expression was observed in 61.1% of the appendix NENs (11 out of 18, Figure 2A) and associated with smaller tumor size (6.62 ± 0.78 vs. 10.29 ± 1.23, p = 0.017, Figure 2B), Table 2. The gene discussed is CDKN2A; the disease is neoplasm.