Likewise, Shi and coworkers reported that knockdown of lncRNA AFAP1-AS1 inhibited tumorigenesis, epithelial-mesenchymal transition, and vasculogenic mimicry by sponging RhoC and altering the ROCK1/p38MAPK/Twist1axys in osteosarcoma cells [21]. This evidence concerns the gene RHOC and osteosarcoma.