It has been also demonstrated that p65 as a part of p65-p50 heterodimer regulates expression of genes that contribute to the metastatic phenotype of melanoma cells that is a consequence of the low level of KIP1 ubiquitination-promoting complex protein 1 (KPC1) associated with limited availability of p50-p50 homodimer involved in suppression of NF-κB-dependent cell proliferation [55]. The gene discussed is RNF123; the disease is melanoma.