This was associated with induction of apoptosis as melanoma cell lines exposed to AG at 0.4 μM exhibited (i) a time-dependent increase in the percentages of annexin-V-positive cells, (ii) elevated percentages of cells with active caspase-3/7, and (iii) increased level of cleaved poly-(ADP-ribose) polymerase (PARP). This evidence concerns the gene CASP3 and melanoma.