In this respect, genetic alterations diversely distributed among melanoma cell lines might determine different levels of CXCL8 transcript as DMBC12, DMBC21, DMBC29, and DMBC22 cell lines harbored several point mutations in IL1B. IL-1β, a product of IL1B expression, is secreted by melanoma and stroma cells and induces NF-κB following IL-1R activation in an autocrine or paracrine manner [60,61,62]. The gene discussed is IL1R1; the disease is melanoma.