Our data are in line with the longstanding but conflicting reports on the potential association of genetic variants of methylenetetrahydrofolate reductase [27,28,29,30], hyperhomocysteinemia and/or folate and vitamin B12 levels with CKD progression in different contexts, including diabetes [28,29,31,32,33,34,35,36]. Here, MTHFR is linked to hyperhomocysteinemia.