Moreover, another type of leukodystrophy, megalencephalic leukoencephalopathy with subcortical cysts, is associated with genetic mutations in the ClC-2-binding proteins GlialCAM and megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1), whose disease-related defects significantly disrupt the subcellular localization of ClC-2 channels in astrocytes and oligodendrocytes, as well as reducing ClC-2 protein stability at the plasma membrane [19,20,21]. This evidence concerns the gene HEPACAM and leukoencephalopathy, megalencephalic.