The above factors are correlated with multiple dysregulated signaling pathways, such as growth factor-mediated angiogenic signaling (vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin-like growth factor (IGF), hepatocyte growth factor (HGF)/c-MET), mitogen-activated protein kinase (MAPK), phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR), and Wnt/β-catenin pathways, which contribute to HCC development and tumorigenesis [8]. The gene discussed is EGF; the disease is hepatocellular carcinoma.