NUP98 and Zika virus infectious disease: As observed for Nup98, the active form of the ZIKV NS2B3 (WT), as well as ZIKV infection, were able to induce a significant reduction in the Nup153 and TPR levels that was not observed in cells expressing the inactive form ZIKV NS2B3-S135A (Mut) (Figure 12), supporting the idea that ZIKV NS2B3 protease degrades directly or indirectly Nup98, Nup153, and TPR while DENV NS2B3 is responsible for the direct or indirect cleavage/degradation of Nup62, Nup98, and Nup153.