HSPG2 and breast cancer: A similar response was observed for the large heparan sulfate proteoglycan Perlecan (Basement membrane-specific heparan sulfate proteoglycan core protein, PGBM), that was found strongly up-regulated in CS-treated synoviocytes CM (fold change = 5.6) and slightly down-regulated in BC-treated sample (fold change = 0.6).