JUP and breast cancer: By contrast, other enzyme inhibitors such as Cystatin-A (CYTA) and several proteins involved in cell-cell adhesion (Desmocollin-1, DSC1; Desmoglein-1, DSG1; Desmoplakin, DESP; Junction plakoglobin, PLAK; Annexin A2, ANXA2) were down-regulated upon both CS and BC treatments.