As possible pathomechanism of VTE in patients with brain tumors, tissue factor and plasminogen activator inhibitor type I, which are among the procoagulant and antifibrinolytic substances, as well as circulating microparticles bearing tissue factor can be found more frequently in high grade glioma than in other brain tumors, and are therefore discussed by several authors [25,26,27,28,29]. This evidence concerns the gene SERPINE1 and brain neoplasm.