What appears as a discrepancy, may result in the same effect: While CD16 expression on NK-cells is anti-tumorigenic and thus reduced in HNSCC [40,42], high levels of CD16 on exosomes—as particularly observed in patients with advanced disease—seem to be pro-tumorigenic as competition of CD16high exosomes with CD16low NK cells for antibody coated malignant cells might result in massive, synergistic immune suppression. Here, FCGR3A is linked to head and neck squamous cell carcinoma.