AKT1 and breast cancer: Both of p70S6 kinase and STAT3 could exert oncogenic potential in breast cancer through a phosphatidylinositide 3-kinases (PI3K)/Protein kinase B (Akt/PKB)/p70S6 kinase signaling pathway [52,53] while RSK is a family of Ser/Thr protein kinases (RSK1-4) that function downstream of the Ras/mitogen-activated protein kinase (MAPK) signaling to trigger cell survival, growth, and proliferation.