Moreover, EVs isolated from the sera of CHC patients not only contain HCV RNA and independently regulate HCV replication via viral receptors, but are also corelated with HSP90, Argonaute RISC Catalytic Component 2 (Ago2), and mir-122, which increase HCV replication by EV-regulated HCV transmission to naive cells [25]. Here, AGO2 is linked to cryohydrocytosis.