PTPRC and leukemia: Figure 4b plots the percentage of human CD45+ cells over all models in the three different compartments over three implantation techniques. With the exception of one model, LEXF 2431, the s.c. implanted leukaemia cells did not circulate in PB or infiltrated the investigated haemopoietic organs. As a consequence, the infiltration rates of the disseminated approaches in BM, PB and spleen were significantly higher compared to the s.c. method (p < 0.0001, Kruskal–Wallis test).