HDAC1 and infection: Considering that this effect was also dampened by knockdown or inhibition of class I HDACs and the evidence that besides A. phagocytophilum and P. aeruginosa also Porphyromonas gingivalis modulates HDAC1 during infections, HDAC1 family members might play a central role in development of an epigenetic mediated tolerance against the pathogens [67].