TGFB1 and neoplasm: Treg cells and tumor-associated macrophages (TAMs) infiltrate the TME, where, together with MDSCs, they release immunosuppressive cytokines, mainly TGF-β, which is largely known to hamper NK cell-mediated tumor killing, including ADCC, by decreasing GZMB and FasL expression in NK cells [14,246,247,248,249,250,251,252].