CASP8 and cancer: Further, a caspase-8-defective mutant characterized by a single amino acid deletion (Leu62del) was described in vulvar squamous carcinoma and a frameshift mutation (1225_1226delTG) is likely responsible for the loss of caspase-8 activity in hepatocellular carcinoma, suggesting that genetic alterations linked to caspase-8 inactivation might vary depending on the type of cancer [64,65].