Although evidence on coronavirus-induced metabolism is scarce, a study has reported that the rapid activation of the p38 mitogen-activated protein kinases (MAPK) pathway was detected in FIPV-infected primary blood-derived feline mononuclear cells, and this activation greatly regulates the production of pro-inflammatory cytokine (tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta) during infection [16]. The gene discussed is TNF; the disease is infection.