Additionally, increased expression of CX3CR1 ex vivo in T cells achieved by the use of the retrovirus vector, and introducing these cells into the body of mice has led to an increase in the homing of these cells to a colorectal tumor [254], which was associated with a high CX3CL1 expression in the tumor and had an anti-tumor effect. Here, CX3CL1 is linked to colorectal neoplasm.