Targeting stroma in a murine model of metastatic pancreatic cancer using the immune modulating effect of hyaluronan degradation by PEGPH20 significantly decreased the immunosuppressive effect of CXCL12/CXCR4/CCR7 signaling axis in CAFs, myeloid, and CD8+ T cells. Here, CXCR4 is linked to pancreatic neoplasm.