Genetic analysis identified a missense variant in the SCN1B gene (NM_199037.4: c.[363C > G]; [363C=] p.[Cys121Trp]; [Cys121=]), previously known to cause Febrile seizures and generalized epilepsy [20] and classified to be likely pathogenic, according to the ACMG guidelines. This evidence concerns the gene SCN1B and generalized epilepsy.