In a previous study, we have demonstrated the protective effect of RLE on glomerular filtration rate (GFR) and proximal tubule reabsorption and, although the exact molecular mechanism whereby anthocyanins act against DN is not fully understood, possible mechanisms could be the attenuation of high-sensitivity C-reactive protein and a reduced expression of sodium-dependent glucose transporter 1 [35,36]. This evidence concerns the gene SLC60A2 and liver dysplastic nodule.