PRKN and Parkinson disease: Notably, genes such as PINK1 and Parkin, which are related to familial-PD forms, are involved in the control of mitochondrial dynamics [74] and several other genetic mutations, including PINK1, Parkin, DJ-1, LRRK2, and α-Syn, have been linked to familial PD and the corresponding gene products are also involved in mitophagy.