HMOX1 and Cerebral ischemia: In models of cerebral ischemia and neuronal cultures, EGCG promotes neuronal protection regulated by the Nrf2/HO-1 pathway by attenuating both ROS production and nuclear factor κB (NF-κB) activation [22], which consequently suppresses the expression of TNFα, IL-1β, IL-6, and iNOS [23].