IL1B and cancer: The plausible explanation of the above presentation could be related to the soluble mediators released by malignant cells within different regions of HCC nodules, which destines the polarization of macrophages by triggering transient early activation of monocytes in peritumoral stroma with high expression of HLA-DR (human leukocyte antigen), interleukin 1 beta (IL-1b) and inducing immunosuppressive M2 phenotypes in cancer nests [71,72,73].