The malignant hepatocytes express glypican-3 and secrete various molecules such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), TGF-β, CCL2 and MCSF to aid and abet the activation and recruitment of TAMs within the peritumoural region of HCC nodules [74]. This evidence concerns the gene GPC3 and hepatocellular carcinoma.