Additionally, these two SNPs remained independently and significantly associated with BCR after adjustment for age, PSA, Gleason score, cancer stage, and surgical margin (hazard ratio (HR) 1.43, 95% confidence interval (CI) 1.16–1.76, P = 9.67 × 10−4 for rs8192935, and HR 1.50, 95% CI 1.24–1.90, P = 9.34 × 10−5 for rs8192950, Table 2). This evidence concerns the gene KLK3 and cancer.