CD4 and cancer: Nanotubes formed from the co-assembly of Coil29 conjugated with a cancer B-cell epitope from the epidermal growth factor receptor class III variant (EGFRvIII), and Coil29 linked to the universal CD4+ T-cell epitope PADRE, are readily internalized by APCs and induce robust antibody production, CD4+ T-cell and CD8+ T-cell responses in mice [56].