Hence, the combined treatment with BEZ235 and regorafenib could significantly suppress the activation of p-mTOR (ser2448), p-p70S6K (Thr389), p-4EBP1 (Thr37/46) and p-4EBP1 (Thr70) in the HCC cells. This evidence concerns the gene EIF4EBP1 and hepatocellular carcinoma.