Notably, failure in acetaldehyde detoxification, due to the inheritance of a dominant-negative allele (rs671) of the aldehyde-catalyzing enzyme acetaldehyde dehydrogenase 2 (ALDH2) that is present in nearly 50% of the Japanese population, is a recognized aggravating condition in Japanese FA patients [29]. The gene discussed is ALDH2; the disease is Friedreich ataxia.