By analyzing nucleotide sequences (see Chapter 2.2, Figure 2A), we discovered in the −90/−52 region of most 7SL RNA and 4.5SH RNA genes sites corresponding to the GC-box consensus (GGGCGG or CCGCCC), which can potentially bind pol II transcription factors, such as Sp1, Krox/Egr, Wilms’ tumor, MIG1, and CREA [50]. Here, SP1 is linked to Nephroblastoma.