APOE and Alzheimer disease: Parental AD shows that PRS excluding APOE is associated with AD over the effect of APOE. When examining the effect sizes for APOE, it is seen that the effect size is smaller in the older group (β = 0.208, SE = 0.005, p < 1 × 10−350) compared with the younger group (β = 0.348, SE = 0.009, p < 1 × 10−350).