IGHG3 and Zika virus infectious disease: Additionally, another work carried out at Pau da Lima community in the city of Salvador, Brazil, showed that the pre-outbreak IgG3 titers against DENV NS1 were positively associated with risk of ZIKV infection but at the same time the presence of IgG1 against same antigen was associated to a decrease in the probability of ZIKV infection [30].