This is highly relevant to our results because IgG3 subclass have been associated to recent DENV infection and are detectable only up to 4 to 6 months after infection, which comprises the period of 3 months of our early-convalescent group showing a trend to control ZIKV replication but not as effective as the DENV-middle convalescent group. The gene discussed is IGHG3; the disease is infection.