Importantly, Weiskopf et al. and others have shown that DENV CD4+ T cells are readily detectable early following DENV infection, and the frequency of DENV-specific CD107a+ CD4+ T correlate with enhanced protection against DENV disease [56, 57] and play a key role in controlling secondary flavivirus infections [35]. The gene discussed is CD4; the disease is Flavivirus Infections.