Accordingly, insulin‐induced activation of Akt1 and Akt2 signalling was diminished in human airway epithelia expressing F508del‐CFTR compared with the cells expressing wild‐type CFTR. 35Alternatively, in cancer cells, dysregulation of channel function or knockdown of CFTR gene inhibited cell viability and autophagy of LNCaP/CP, a prostate cancer cell line, via activation of Akt/mTOR signalling.36 Here, INS is linked to Familial prostate cancer.