As Akt is known as an upstream regulator of p53/Bax and Bcl2‐mediated apoptotic pathway,25 and PI3K/PTEN/Akt pathway appears as most frequently altered signalling pathway in malignant gliomas,2, 26 we speculated that CFTR might suppress apoptosis via PI3K/Akt pathway. The gene discussed is BAX; the disease is malignant glioma.