Recently, an increasing number of studies have reported that the AKT and STAT3 signaling pathways regulate B-cell lymphoma-2 (Bcl-2), proliferating cell nuclear antigen (PCNA), CyclinD1 and other factors and have obvious biological effects on tumors such as oral cancer, renal cancer and follicular lymphoma [18–20]. This evidence concerns the gene PCNA and lip and oral cavity carcinoma.