Notable genes that show changes in splicing include the splicing factors MBNL1 and MBNL2. Splicing of these genes was also changed in tissue from a myotonic dystrophy mouse model (35) and in a comparison of FECD_REP and FECD_NR tissue by Fautsch and colleagues (36,37). The gene discussed is MBNL1; the disease is myotonic dystrophy.