Alternatively, cytosolic NADH/NAD+ may regulate p53 itself, possibly via NAD(P)H:quinone oxidoreductase 1 (NQO1) (Khutornenko et al., 2010; Asher et al., 2001; Asher et al., 2002), which could have implications for cancer biology. The gene discussed is NQO1; the disease is cancer.