Germline analysis of 76 cancer predisposition genes revealed the heterozygous c.914T > C (p.Phe305Ser) variant in the FH. Loss of heterozygosity for FH was detected in the tumor, and immunohistochemistry performed at this time showed loss of FH staining (Figure 2b) and positive 2SC staining (Figure 2c). This evidence concerns the gene FH and neoplasm.