INSR and polycystic ovary syndrome: Because the pathogenesis of PCOS is complex and different genome-wide association studies (GWASs) conclusions are more heterogeneous [60], multiple SNPs mutations may affect metabolic and endocrine profiles in the same PCOS patient, such as insulin receptor gene (INSR) and luteinizing hormone/choriogonadotropin receptor (LHCGR) [61].