DYRK2 and intestinal cancer: In the same way, miR-662, miR-208a, miR-338-3p, miR-499, and miR-187-3p directly downregulate DYRK2 expression in colorectal cancer cells, fibroblasts, human intestinal cancer (HIC) cells, cardiomyocytes, and liver cancer cells, respectively [21–25].